Updated on January 21, 2020.
Medical content reviewed by Dr. Joseph Rosado, MD, M.B.A, Chief Medical Officer
cannabinoids were identified in sativa cannabis, and one was found to be significantly
more potent than THC (tetrahydrocannabinol). The rigorous study, published in the
journal Scientific Reports, was conducted by Italian researchers who
have used high-tech tools to isolate, identify, and understand the more than
150 cannabinoids in marijuana. The newly identified cannabinoids were named THCP
(a type of THC) and CBDP (a type of CBD).
suggested that the psychotropic effects of cannabis, traditionally associated
with THC, may be partly attributable to the amount of THCP in a strain, and it
may explain why people respond differently to cannabis therapy, even with an
equal THC dose. “In our opinion,
this compound should be included in the list of the main phytocannabinoids to
be determined for a correct evaluation of the pharmacological effect of the
cannabis extracts administered to patients,” the authors wrote.
The study found that THCP bonded with the CB receptors in the
body at 30 times the potency of THC, suggesting exponentially stronger psychotropic
effects. In mice, THCP produced the same behavioral effects as THC, but at about
half the dose.
It is not known whether THCP will have the same effects in people
and it’s also unclear how much THCP common marijuana strains contain. The
researchers are now studying the composition of different cannabis strains to
determine levels of THCP and other cannabinoids.
Identifying these minor cannabinoids could lead to the
cultivation of strains that have more focused therapeutic effects, the authors