Diabetic Peripheral Vascular Disease


marijuana and dpvd
While medical marijuana can’t reverse diabetic peripheral vascular disease (PVD), it can benefit individuals with diabetes due to its anti-inflammatory properties. However, this isn’t all the herb can do. It is powerful against an array of other symptoms of PVD as well.

What Is Diabetic Peripheral Vascular Disease?

Peripheral vascular disease, also referred to as peripheral arterial disease (PAD), is a circulatory condition marked by narrowed blood vessels reducing blood flow to the limbs.

peripheral arterial disease

Although it’s a huge risk factor for amputation of the lower extremity, it can also lead to cerebrovascular disease in the brain or symptomatic cardiovascular disease in the heart. While we know a lot about the disease itself, assessing it and managing PVD in people with diabetes isn’t as clear and poses particular problems. As of now, there aren’t any established guidelines for caring for individuals with both PVD and diabetes.

PVD occurs when you have buildup on your blood vessel walls that leads to narrowing. Generally, those with type 2 diabetes, who are also at a higher risk of heart disease and high cholesterol, develop it. Around one in three individuals with diabetes who are over 50 years old have peripheral arterial disease, according to the American Diabetes Association. Doctors usually diagnose the condition when it causes foot and leg problems.

Risk Factors for Diabetic Peripheral Vascular Disease

Diabetic patients already have an increased risk for PVD. Certain risk factors pose an even greater risk of them developing the disease. These risk factors are:

  • Smoking
  • Being obese or overweight
  • Having high LDL — bad — cholesterol
  • being physically inactive
  • Having a family history of stroke, cardiovascular disease or PVD
  • Having high blood pressure
  • Having a previous history of stroke or coronary artery disease, including angina, bypass surgery, angioplasty or heart attack

To reduce your risk of PVD, you need to take extra care of your blood vessels.

Symptoms of Diabetic Peripheral Vascular Disease

Many people with PVD don’t even know they have the disease because many times it doesn’t cause symptoms. Those who do have symptoms may experience:

  • Inflammation
  • Leg weakness
  • Hair loss on the legs and feet
  • Brittle toenails
  • Pain in calf or thigh muscles when walking
  • Painful hips
  • Toenails grow slowly
  • A cold feeling in the lower leg or foot
  • Leg skin turns bluish or pale or becomes shiny
  • Ulcers or sores on the feet and legs that don’t heal or take a long time to heal
  • Erectile dysfunction
  • Trouble finding a pulse in the foot or leg
  • Numbness in legs

Causes of Diabetic Peripheral Vascular Disease

Diabetes can harm your arteries. If you don’t control your diabetes well, your blood sugar levels can become too high and make your artery walls rough. Plaque, a waxy substance in the blood, can build up on your artery walls. This type of plaque has cholesterol and makes it difficult for your blood to flow through the arteries. When this happens, it limits oxygen and blood flow to your legs and arms, causing tissue damage.

The most at risk for tissue damage are your feet. If the tissue damage becomes severe, you could need your feet, toes or even legs amputated.

Physical Effects of Diabetic Peripheral Vascular Disease

If blood vessel plaque buildup — also called atherosclerosis — is what’s causing your peripheral vascular disease, you’re also vulnerable to:

  • Heart attack and stroke: The atherosclerosis causing the symptoms of PVD isn’t restricted to your legs. You can also have a buildup of fat deposits in the arteries that supply blood to your heart and brain.
  • Critical limb ischemia (CLI): CLI starts as an injury, open sores that won’t heal or an infection of your legs or feet. CLI occurs when these infections or injuries progress, causing tissue death, which can require amputation of the limb affected.

A doctor can assess the impact of PVD by the presence of symptoms, its progression and excess cardiovascular episodes linked to systemic atherosclerosis. Around 27 percent of PVD patients show symptom progression over a five year period with four percent losing a limb, reports the American Diabetes Association.

Although researchers have not been studying the natural history of PVD in individuals with diabetes long-term specifically, prospective clinical trials assessing risk interventions have shown the cardiovascular episode rates in PVD patients with diabetes are higher than individuals without diabetes.

Mental Effects of Diabetic Peripheral Vascular Disease

In a study published in Vascular Medicine, researchers evaluated lower leg symptoms in peripheral vascular disease about mood states like depression, anxiety, and anhedonia — the inability to feel pleasure. Out of all participants, 29 percent had anxiety, 30 percent had depression and 28 percent had anhedonia.

Experiencing pain while resting was associated independently with depression, anxiety, and anhedonia. Individuals with atypical leg symptoms had twice the risk of anxiety.

There’s an important need to deal with depression in PVD patients, especially those who have characteristics placing them at a higher risk. Vascular care providers are typically the primary contact for initially assessing symptoms of depression. Once diagnosed, they may refer the patients to mental health providers to prevent the worsening of both PVD and depression.

Diabetic Peripheral Vascular Disease History

There isn’t much demographic data related to PVD distribution, and most date back to the 1960s. In the 1960s, three men had PVD for every woman diagnosed, whereas now in a present study, there’s a 3:2 gender ratio.

Given the restrictions in being able to compare different populations over a period of 50 years, it’s hard to know precisely whether this signifies a genuine distribution change or a change in sampling. If it is a prevalence change, then the reasoning behind this isn’t clear but could be related to the higher prevalence of female smokers in the latter half of the 20th century.

Current Treatments Available for Diabetic Peripheral Vascular Disease and Their Side Effects

dpvd treatments

To diagnose PVD, your doctor could use the ankle-brachial index. This compares the blood pressure in your ankle to the blood pressure in your arm. If your ankle blood pressure is lower than your arm blood pressure, you could have PVD. If taking your blood pressure alone can’t give your doctor a clear PVD diagnosis, they might suggest other diagnostic measures such as a Doppler ultrasound or magnetic resonance angiography.

Prevent Peripheral Vascular Disease

Your doctor can help you control several of the risk factors mentioned above to reduce your chances of developing PVD and slow its progression. People with diabetes need to be particularly careful to keep their blood glucose levels as normal as they can.

Also, it’s essential to participate in regular physical activity. Your doctor may also prescribe you medications or special footwear. You can reduce your risk of stroke or heart attack and enhance your quality of life by taking the steps necessary to reduce your risk of PVD.

Manage Cardiovascular Factors

Individuals with PVD have a high risk of stroke and heart attack, so they need to manage their cardiovascular risk factors. The doctor will likely advise you to:

  1. Eat a healthy, well-balanced diet to manage your weight and blood glucose levels.
  2. Quit smoking if you’re a smoker.
  3. Follow a supervised and moderate exercise program where you rest when you’re feeling leg pain. Walking a few times a week for around a half hour a day is ideal.
  4. Lower your saturated fat, cholesterol, and sodium in your diet to reduce your cholesterol levels and blood pressure.
  5. Take aspirin or antiplatelet drugs to thin your blood which will help your blood flow through restricted or narrow arteries. Side effects of antiplatelet drugs may include:
  • Dizziness or a headache
  • Constipation or diarrhea
  • Nausea
  • Nosebleeds
  • Abdominal pain or stomach ache
  • Increased bleeding
  1. Take medications prescribed to you and monitor your blood pressure.
  2. Take any cholesterol or diabetes medicines as prescribed. Gas, upset stomach or diarrhea could occur with some diabetes medications. Some side effects of cholesterol medications are:
  • Constipation
  • Diarrhea
  • Muscle soreness
  • Weakness
  • Nausea
  • Vomiting
  • Stomach cramps
  • Pain
  • Dizziness


In severe PVD cases, your doctor might suggest surgery. They’ll use an arterial bypass or balloon angioplasty to reroute or open restricted blood vessels.

Recent Developments in Diabetic Peripheral Vascular Disease

Clinical trials to study PAD and evaluate potential treatments include:

  • Measuring endothelial function with PVD in patients who are undergoing hyperbaric oxygen therapy
  • Post-operative diabetic PVD treatment with platelet reactivity unit guidance
  • A study comparing a couple of techniques for expanding stents placed in people’s legs

How and Why Marijuana Can Be an Effective Treatment for Diabetic Peripheral Vascular Disease

Cannabis can help with peripheral vascular disease complications including inflammation, diabetes, and neuroprotection.

1. Inflammation

Medical marijuana has received credit as an anti-inflammatory for a long time, and inflammation is present in people with peripheral vascular disease. In one study, however, researchers found it’s not just the psychoactive compounds responsible for its anti-inflammatory properties, but also a compound people take daily in a vegetable nutriment.

The hemp plant has more than 450 distinct compounds, with only three of them having intoxicating effects. These compounds activate the body’s CB1 and CB2 receptors. Although the central nervous system’s CB1 receptor influences perception, the tissue’s CB2 receptor plays a significant role in hindering inflammation.

2. Diabetes

Researchers have conducted studies since 2005 on medical marijuana’s benefits in patients with diabetes. The American Journal of Medicine (AJM) published a study in 2013 that quickly became the foundation for talking about medical weed’s ability to treat the disease.

Although some still doubted the effectiveness of cannabis for slowing down the onset of type 2 diabetes, the AJM’s study left little doubt cannabis was healthful and helpful for individuals diagnosed with diabetes, both type 1 and 2, as well as associated complications like PVD.

The study found current marijuana users were reporting they could metabolize their carbohydrates “better” when compared with non-users. The main finding of this research was the cannabis user’s fasting insulin levels were not just lower, but also seemed to be “less resistant” to their body’s natural insulin.

This enabled them to sustain regular blood-sugar levels, reducing their need for insulin injections in type 1 diabetes, and potentially slowing down type 2 diabetes progression by helping their body naturally manage their sugar levels.

3. Neuroprotectant

Cannabis has “neuroprotective” effects, activating the body and brain’s receptors to help to prevent nerve inflammation and decrease the pain of neuropathy. It also works as a “vasodilator,” helping improve circulation and keep blood vessels open.

What Side Effects/ Symptoms of Diabetic Peripheral Vascular Disease Can Medical Marijuana Treat?

dpvd symptoms

Besides potential benefits in the better metabolization of carbohydrates, less resistance to natural insulin and vasodilator capabilities, medical marijuana can help treat diabetic peripheral vascular disease symptoms such as:

  • Pain
  • Depression
  • Anxiety
  • Trouble sleeping

The American Alliance for Medical Cannabis (AAMC), in 2005, released a report showing five main areas where cannabis was thought to help those living with diabetes. The report indicated:

  1. Medical pot could stabilize blood sugar
  2. Cannabis’s “neuroprotective” properties helped it activate the body and brain’s receptors to reduce neuropathic pain
  3. Marijuana helps reduce blood pressure by keeping blood vessels open
  4. Medical weed works as an anti-spasmodic agent
  5. Cannabis relieves discomfort and pain associated with gastrointestinal upset and muscle cramps more easily than Neurotonin and other counterparts by easing restless leg syndrome symptoms associated with diabetes, promoting better sleep and helping the overall body function

Also, the AAMC stated rubs or topical ointments with CBD oil could reduce tingling sensations in the feet and hands and neuropathic pain.

Best Strains of Marijuana to Use for Symptoms of Diabetic Peripheral Vascular Disease

There are many different kinds of medical marijuana strains you can try depending on which symptoms you most want to target.

different strains

Some suitable medical cannabis for diabetes are:

  • Sour Tsunami
  • Harlequin
  • Cannatonic
  • Black Beauty
  • Pennywise
  • Doug’s Varin
  • Northern Lights

Good inflammation strains:

  • God Bud
  • Cannatonic
  • Great White Shark

Strains for Trouble Sleeping

  • Purple Urkle
  • Godfather OG
  • Granddaddy Purple

Strains for Depression

  • Pineapple Express
  • Jack Herer
  • Harlequin

Best Methods of Marijuana Treatment to Use to Treat Side Effects and Symptoms of Diabetic Peripheral Vascular Disease

Cannabis treatments for diabetic peripheral vascular disease come in several forms:

  1. Ingestion: Consuming edibles, drinking tea and taking tinctures to find relief from symptoms for many hours.
  2. Inhalation: Smoking and vaping for fast relief, but only lasts for a couple of hours. Patients should speak to their doctors about the respiratory risks of smoking cannabis.
  3. Topical: Applying balms, salves, and lotions to your skin to relieve localized inflammation, pain and neuropathy.

Start the Medical Marijuana for Diabetic Peripheral Vascular Disease Relief Process

If you’re thinking about obtaining a marijuana recommendation for diabetic peripheral vascular disease, you can search the listings on MarijuanaDoctors.com for licensed and qualified marijuana doctors who understand the benefits of medical cannabis and know how well it can help with disabling symptoms of PVD and other health conditions.

You’ll also be able to book an appointment with a cannabis doctor so you can discuss your marijuana and diabetic peripheral vascular disease treatment plan, then browse the comprehensive list of dispensaries to find your cannabis products.

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  1. https://www.nhlbi.nih.gov/health-topics/peripheral-artery-disease#Risk-Factors
  2. http://www.diabetes.org/living-with-diabetes/complications/heart-disease/peripheral-arterial-disease.html
  3. https://www.ncbi.nlm.nih.gov/pubmed/19808714
  4. http://www.amjmed.com/article/S0002-9343(13)00200-3/abstract