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Medical Marijuana and Cancer, Testicular

marijuana and testicular cancer

It’s impossible to overemphasize what an impact cancer has on anyone who has been diagnosed with the disease. When you have cancer, you can have some tough treatments that can cause severe side effects in addition to the cancer symptoms.

Testicular cancer is just one of the types of cancer that affects men and is quite common. Medical marijuana for testicular cancer can help ease the pain, nausea and other harsh side effects that come with pharmaceutical cancer treatments. And, with the increasing availability of refined and concentrated cannabinoid treatment options, patients can now find relief from this horrible disease.

What Is Testicular Cancer?

common cancer in men ages 15 to 35
Men get testicular cancer in their testes (testicles). Their testes are located in the loose bag of skin called the scrotum that’s located underneath their penis. Testicles are responsible for producing the sex hormones in men and the sperm for reproduction. Testicular cancer isn't as common as some other types of cancers, but it is a common cancer in men in the U.S. ages 15 through 35. This form of cancer is highly treatable and continues to be so even after it has spread past the man's testicles. There are several treatment options, depending on the type and stage of your cancer.

Types of Testicular Cancer

A man's testicles consist of various types of cells. Each of these cells can develop into different types of cancer. Since each cancer is treated differently and has a different prognosis, it's important to determine which type you have. Read about the types of testicular cancer below.

Germ Cell Tumors

Over 90 percent of testicular cancers develop in special cells called germ cells. These cells are the ones that produce sperm. Two primary types of germ cell tumors (GCTs) that can develop in men are:

  • Seminomas
  • Non-seminomas (consist of yolk sac carcinoma, embryonal carcinoma, teratoma or choriocarcinoma)

Physicians can look under a microscope at the cells to determine what type you have.

These two types of GCTs occur about equally, and may contain both non-seminoma and seminoma cells. These mixed GCTs are treated as non-seminomas since they tend to grow and spread similar to non-seminomas.

Seminomas

Out of the two, seminomas usually grow and spread more gradually than non-seminomas. The two primary subtypes of these tumors are spermatocytic seminomas and typical, or classical, seminomas. Physicians can look under a microscope to tell them apart.

  • Spermatocytic Seminoma: This seminoma is rare and often occurs in older men. Men are typically around 65 years of age when receiving a spermatocytic seminoma diagnosis. Spermatocytic tumors grow more gradually than classical seminomas and aren't as likely to spread to other areas of your body.
  • Classical Seminoma: Over 95 percent of seminomas end up being classical. Men between the ages 25 and 45 are more prone to them.

Some seminomas may increase human chorionic gonadotropin (HCG) protein blood levels. A simple blood test can detect HCG and doctors consider it a tumor marker for certain kinds of testicular cancer. Doctors can use it to give you a diagnosis or to see how you're responding to your treatment.

Non-Seminomas

These types of GCTs typically occur in men who are between their late teen years and in their early 30 years. There are four primary types of non-seminoma tumors known as:

  • Yolk sac carcinoma
  • Embryonal carcinoma
  • Teratoma
  • Choriocarcinoma

Many tumors are a combination of different types. However, the treatment approach is somewhat similar with most non-seminoma cancers. Consult with your physician about the various types of testicular cancer, so you can receive a full explanation of the type you have.

History of Testicular Cancer

Before the platinum combination chemotherapy era, radiation and chemo could cure testicular cancer in its earliest stages. But for patients who were in their advanced stages, it was almost uniformly fatal, according to the Journal of Clinical Oncology. The lack of accurate and convenient imaging techniques made managing it effectively more challenging.

Following the World War II years, radiation, orchiectomy with retroperitoneal lymph-node dissection (RPLND) or both were the most successful treatment options for testicular cancer regardless of histology.

incidence rates for testicular cancer increased
Incidence rates for testicular cancer in the U.S. have increased over the past 40 years. However, death rates for this type of cancer from 1990 to 2014 have gradually declined by 0.4 percent each year.

Effects of Testicular Cancer 

Testicular cancer signs and symptoms include discomfort or swelling in your scrotum. However, they could also be symptoms caused by another condition. Regardless, consult with your doctor if you're experiencing any of the following symptoms:

  • A change in the feeling of your testicles.
  • A painless swelling or lump in either of your testicles.
  • A sudden fluid buildup in your scrotum.
  • A dull ache in your groin or lower abdomen.
  • Discomfort or pain in your scrotum or testicles.

You may also be dealing with many different emotions during or after your treatment. Many people go through this. 

You might think about dying and death a lot. You may be more aware of how your cancer is affecting your friends, family and career. Your relationships with those around you may change. You may be concerned with things like having sex, dating or fathering children.

There may be unexpected problems that cause concern, such as the financial stress, that result from your treatment. Because you're likely seeing your doctor and health care team less often once your treatments have concluded, you'll have a lot more time to yourself. Having too much time without much to do can make some people anxious.

Having cancer can feel and get lonely. You shouldn't try to handle everything yourself. And if you don't include your family and friends, they may feel shut out. Let them in and let others in who are trying to help you.

Testicular Cancer Statistics

According to the testicular cancer estimates by the American Cancer Society, in 2017 in the U.S.

  • There have been around 8,850 new testicular cancer cases diagnosed.
  • There have been around 410 testicular cancer-related deaths.
  • The lifetime risk to a man of dying from testicular cancer is low: only one in 5,000.
testicular-cancer-stats

Testicular cancer statistics according to the US National Library of Medicine National Institutes of Health include:

  • Testicular cancer is rare and accounts for one percent of malignant tumors in men.
  • Testicular cancer is the most common malignancy diagnosed among men who are 15 to 40 years old.

Current Treatments Available for Testicular Cancer and Their Side Effects 

The success rate of testicular cancer treatment is around 95 percent, meaning 95 percent of all patients with the cancer receiving treatment will make a complete recovery. The sooner the patient receives his diagnosis and receives treatment, the better prognosis he'll have.

Treatment options for testicular cancer typically involve surgery, chemotherapy, radiotherapy or a combination.

Testicular Cancer Surgery

Orchiectomy

Orchiectomy is usually the first treatment doctors try. Surgeons surgically remove the testicle to keep the tumor from spreading. Surgery may be all that's needed if your diagnosis and treatment is stage one. During an orchiectomy, your surgeon will give you a general anesthetic. The surgeon makes a small incision in your groin and removes your testicle through this incision.

You'll stay in the hospital for several days. If you still have one of your testicles left following your operation, this surgery shouldn’t affect your sex life and reproduction abilities. 

If both testicles were removed, you’ll be infertile following the operation. You won't be able to produce sperm. If you’re looking to have kids one day, you'll want to consider banking your sperm before your operation, where your sperm is stored at a sperm-bank before the surgeon removes your testicles. Chemo and radiotherapy also affect your long-term fertility.

Side effects of an orchiectomy may include:

  • Bleeding, pus or redness from your incision site.
  • Inability to urinate.
  • Fever that's over 100°F (37.8°C).
  • Loss of sensation or feeling around your scrotum.
  • Hematoma (blood in the scrotum that looks like a big purple spot).

Lymph Node Surgery

If your cancer has spread to your lymph nodes, a surgeon will have to remove them surgically. Typically, this involves your lymph nodes in your chest and abdomen. In some cases, this surgery may also lead to infertility. While serious complications are rare, they can happen. Around five to 10 percent of patients will experience temporary side effects, such as wound infections or bowel obstruction, following their surgery.

Chemotherapy

Chemo is a treatment option where the doctor prescribes medication containing chemicals that destroy cancer cells. Cytotoxic medication keeps the cancer cells from separating and growing.

You’ll typically receive chemo if you have an advanced stage of testicular cancer where it’s spread to other areas of your body. You'll either take oral tablets by mouth or receive an injection. Unfortunately, chemo not only attacks cancerous cells but healthy cells too. Therefore, you'll experience some temporary side effects that can be quite unpleasant such as:

  • Hair loss
  • Nausea
  • Vomiting
  • Tiredness
  • Mouth sores
  • Malaise

You can experience unpleasant and uncomfortable side effects of chemotherapy. However, the ability for patients to manage these side effects has improved considerably. Medical marijuana can help with some of the side effects of chemotherapy, especially nausea and vomiting.

Radiation Therapy

Radiation therapy is a procedure where the surgeon uses high-energy X-ray beams or particles to destroy your cancer cells. Radiotherapy damages the DNA that's inside the tumor cells and destroys their reproduction ability. When you have seminoma testicular cancer, you'll likely need radiation therapy along with surgery.

Radiation therapy also prevents the return of cancer. If your cancer has spread to your lymph nodes, you'll most likely need this therapy. 

Temporary side effects of radiotherapy include:

  • Rashes
  • Tiredness
  • Joint stiffness
  • Muscle stiffness
  • Nausea
  • Loss of appetite

How Marijuana Can Be an Effective Treatment for Testicular Cancer

Although there's a study that links marijuana to testicular cancer, it doesn't make any definitive conclusions or show a cause-and-effect relationship. And there are handfuls of other studies showing that cannabis as testicular cancer treatment helps increase your appetite and reduces nausea and pain associated with chemotherapy. 

University of East Anglia scientists have shown how marijuana's main psychoactive ingredient can actually reduce the growth of tumors in cancer patients. Published research today shows the existence of earlier signaling platforms responsible for the success of the drug in shrinking tumors.

The hope is that the findings can help with the development of a synthetic equivalent that had anti-cancer properties. The scientists induced tumors in mice using samples of human breast cancer cells. They then dosed the tumors with THC, a cannabis compound. The scientists found there were a couple of cell receptors in particular that caused the anti-tumor effects of the drug.

THC acts through a specific cell receptor family known as cannabinoid receptors. However, the scientists couldn't decipher which of the receptors caused THC's anti-tumor effects. According to the scientists, the CB2 and GPR55 joint interaction mediated these effects. These are two compounds found in the cannabinoid receptor family. The scientists' findings helped to explain the effects of THC at high and low doses on tumor growth.

What Symptoms of Testicular Cancer Can Medical Marijuana Treat?

Medical cannabis for testicular cancer has proven to be extremely beneficial for improving patient’s well-being and often assists patients who are having adverse reactions to traditional medicine treatments like chemo and radiation. Marijuana also doesn’t have many of the side effects that both chemotherapy and radiation do, such as:

  • Nausea
  • Vomiting
  • Lack of appetite
  • Extreme pain throughout body
  • Fatigue 

Testicular cancer is a specific type of cancer that tends to affect between 7,500 and 8,000 men each year. This is considered the most common type of cancer that is found in males between the ages of fifteen and forty years old. Thankfully, medical marijuana has been a proven treatment to reduce the symptoms of chemotherapy in cancer patients. Chemotherapy although the usual treatment for this type of cancer usually brings along the side effects that are not loved.

Medical marijuana alleviates symptoms of nausea, a symptom directly associated with receiving chemotherapy. It also helps increase appetite as a stimulant, as appetite loss is a major factor when undergoing chemotherapy. Another piece of exceptional news is that medical marijuana has been proven through clinical studies to slow the rate of cancer cell growth and eliminates the multiplying of these cells to kill them off.

marijuana can provide 100% nausea and vomiting relief after chemo

Other research included data collected on 748 patients who smoked cannabis before or after their chemo and 345 patients who took an oral THC tablet. The patients who smoked the marijuana experienced up to 100 percent nausea and vomiting relief, while the patients who took the THC tablet experienced up to 88 percent relief.

According to these studies, smoking cannabis is a very effective treatment for the side effects of chemo such as nausea and vomiting. However, smokeless inhalation devices would definitely reduce potential harmful effects of smoking medical pot.

Best Strains of Marijuana to Use for Testicular Cancer 

Thankfully, there are marijuana strains available that are designed specifically to help patients experiencing the unpleasant and uncomfortable side effects listed above. Some cancer-fighting strains may include:

  • ACDC (Hybrid): ACDC provides pain relief from chemo, and other systemic treatment side effects patients have to endure.
  • Granddaddy Purple (Indica): Those suffering with appetite loss due to cancer treatments can benefit from this strain as it brings the appetite back. It helps those who have experienced significant weight loss associated with their decreased appetite.
  • Northern Lights (Indica): Cancer patients can find nausea relief with this strain after they've gone through radiation or chemo treatments.
  • Charlotte's Web (Sativa): The charlotte’s web strain is extremely high in CBD, which means it provides relief to a whole range of cancer symptoms, but doesn't give that psychoactive effect like THC.
  • Chocolope (Sativa): Patients who experience fatigue or are worn out from their cancer treatments will find relief from energy and liveliness with this strain.

Best Methods of Marijuana Treatment to Use to Treat Testicular Cancer Symptoms

Of course, smoking cannabis is still the most common method of using the drug in the U.S. It's the fastest way to get the beneficial chemicals of cannabis in your body. Using a glass pipe, rolling a joint or smoking out of a water pipe or a bong are traditional methods.

Smoking is an efficient and quick way to get an optimum dose of those effective cannabinoids into your system. You'll feel the effects almost instantly, and once you reach your desired relief, you can simply stop smoking.

However, smoking does pose an increased risk of respiratory issues. Some other great methods of getting your marijuana treatment include:

Connect With a Medical Marijuana Doctor for Testicular Cancer or Locate a Dispensary

To learn more about cannabis for testicular cancer and to find your perfect strain, search for a medical marijuana dispensary or doctor today. Here at Marijuana Doctors, we provide patients, including testicular cancer patients, transparency to select a doctor, set an appointment, and learn more about the benefits of medical marijuana.

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This information is not provided by medical professionals and is intended only to complement, and not to replace or contradict, any health or medical advice or information provided by healthcare professionals. If you have any questions, please contact your doctor or other healthcare professional.

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