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Medical Marijuana and Chronic Inflammatory Demyelinating Polyneuropathy

marijuana and cipd

You’re probably aware of the benefits medical cannabis provides. Medical marijuana has characteristics that can alleviate common symptoms — especially pain and muscle spasms — of some conditions, including chronic inflammatory demyelinating polyneuropathy (CIPD).

Using medical marijuana for CIPD has helped patients manage the pain and inflammation associated with this condition, as well as other symptoms. It may even slow down the progression of the disease.

What Is Chronic Inflammatory Demyelinating Polyneuropathy?

CIPD is a long name to describe a medical condition that causes a handful of debilitating symptoms like pain, muscle weakness or paralysis, fatigue or loss of sensation in areas of your body. Between 5,000 and 10,000 individuals in the U.S. are affected by this condition at any one time, reports GPS/CIPD Foundation International.

cipd-stats

CIPD is a nerve disease, bringing pain, numbness and weakness that can occur at any time during your life. Experts don't know exactly what causes this disorder. A prevailing theory is that the roots of your nerves swell and destroy the fatty tissue (myelin sheath) around your nerves, leading to CIDP. This can result in impaired limb function and progression of other symptoms.

You may experience a slow symptoms decline over an eight-week period or more, and then have a few months of slow improvement or remissions. You can also relapse anytime over the years and never fully recover. Although CIDP is similar to other diseases, like progressive inflammatory neuropathy or Guillain-Barré syndrome (GBS), the difference is that an infectious or viral doesn't precede it.

History of CIDP

CIDP is believed to be the chronic form of acute inflammatory demyelinating polyneuropathy (AIDP), which in the U.S. and Europe is the most common form of GBS. Guillain-Barré syndrome progresses over a three- to four-week period, before improving after a few months and disappearing. CIDP, on the other hand, usually doesn't improve unless you are receiving ongoing treatment.

CIPD is a difficult disorder to diagnose. Because it is a rare condition, physicians often have to rule out other diseases before they can arrive at a CIDP diagnosis. Testing for CIDP typically involves undergoing a nerve conduction test, which tells your doctor how fast your nerve impulses make their way through your body. Also, your doctor may order urine tests and a spinal fluid analysis to help to rule out other conditions that may be causing your symptoms.

Symptoms of CIDP

CIDP often comes on secretly and develops slowly. It may gradually progress, or you can relapse — both with either partial or complete remission between its return. You will experience periods where the disease worsens and then an improvement in your condition that typically lasts for a few weeks to several months. To receive an official diagnosis of CIDP, your symptoms must last over eight weeks.

Reported symptoms of the condition include:

  • Lack of feeling or weakness in the feet, leading to problems walking.
  • Weakness in feet that causes trouble using hands, arms or legs.
  • Sensation changes, such as pain, decreased sensation, tingling, numbness or burning

Other symptoms associated with CIDP include:

  • Pain
  • Fatigue and insomnia
  • Depression
  • Uncoordinated or abnormal movement
  • Motor deficits
  • Double vision

You may also have difficulty swallowing, slurred speech, changing voice or hoarseness.

Effects of CIDP

Every person's outcome varies. You may experience repeated episodes of the symptoms, or they may continue long-term. With ongoing treatment, full recovery is possible. However, it's not uncommon to suffer permanent loss of your nerve function.

Some potential complications and effects of CIDP include:

  • Pain
  • Unnoticed or repeated injury to an area of your body
  • Permanent loss or decreased sensation in areas of your body
  • Permanent paralysis or weakness in areas of your body
  • Side effects of medication to treat the condition

If you experience any loss of sensation or movement in any area of your body, it’s important to call your doctor, particularly if your symptoms worsen.

CIDP Statistics

Statistics from the journal Neurology reported by the National Institutes of Health show:

  • Chronic inflammatory demyelinating polyneuropathy prevalence ranges from 1.9 to 7.7 per 100,000. It's reported to occur more in patients who have diabetes mellitus, although there's been no definitive testing.
  • The mortality rate of CIDP has declined to 1.3 percent, with 7 percent of patients not having to be confined to a wheelchair.
cipd-mortality-rate

CIDP affects up to 3.6 million people each year, with around 40,000 U.S. patients affected at any one time, according to the American Association of Neuromuscular & Electrodiagnostic Medicine.

Current Treatments Available for CIDP and Their Side Effects

Early treatment is essential to prevent nerve damage. It can also decrease the severity of your symptoms and prevent them from getting worse.

CIDP treatment is somewhat of an art. Having an experienced physician and autoimmune disorder specialist working with you is key to a better outcome. If treated early, you’re more likely to respond well to the treatment and limit peripheral nerve damage. Early treatment also helps improve function and quality of life, and can help slow the progression of CIDP. Occasionally, early treatment has been able to cure the condition altogether.

CIDP treatment may include:

Corticosteroids

Corticosteroid treatments slow your immune system and reduce inflammation. 

Corticosteroid treatment comes with many side effects that range from mild to severe. Side effects of corticosteroids are apparent when you take them for extended periods of time or at higher doses.  

Corticosteroids can cause:

  • High blood pressure
  • Headaches
  • Swelling in the legs
  • Facial hair growth
  • Muscle weakness
  • Loss of potassium
  • Glaucoma
  • Cataracts
  • Easy bruising or thinning of skin
  • Moon face or puffiness of face
  • Slow wound healing
  • Menstrual irregularity
  • Rounding of the upper back (buffalo hump)
  • Loss of diabetes control
  • Ulcers in the small intestine and stomach

Using corticosteroids for a prolonged period can lead to obesity, convulsions and even psychiatric disturbances such as mood swings, euphoria, personality changes and depression. 

Intravenous Immunoglobulin  

Your physician may inject you with concentrated antibodies from healthy people. These injections slow the immune response of your body. 

You may experience mild or moderate side effects, such as:

  • Headaches
  • Chills
  • Lower back pain
  • Myalgia
  • Nausea
  • Flushing
  • Hypotension
  • Tachycardia
  • Wheezing

Plasma Exchange

With this treatment, you'll receive plasma through an IV to slow down your immune system.

According to a study of 5,235 procedures performed, 12 percent produced side effects in patients treated.

Common side effects experienced were:

  • Chills
  • Fever
  • Muscle cramps
  • Urticaria
  • Paresthesias

Although most side effects have very little or no clinical significance, plasma exchange has led to 28 severe complications among patients, including two respiratory arrests and one cardiac arrest. 

Immunotherapy

Immunotherapy treatment interrupts your immune system to keep it from harming the myelin.

Immunotherapy affects people in different ways. Skin reactions at the needle site are most common, with other side effects including:

  • Pain
  • Soreness
  • Swelling
  • Rash
  • Redness
  • Itchiness

You may also experience flu-like symptoms such as:

  • Chills
  • Fever
  • Fatigue
  • Dizziness
  • Weakness
  • Trouble breathing
  • Joint or muscle aches
  • Nausea or vomiting
  • High or low blood pressure
  • Headaches

Other side effects you may experience include heart palpitations, diarrhea, sinus congestion and risk of infection. As with any treatment, immunotherapy can cause severe allergic reactions that could prove fatal, although rare.

Physical Therapy and Prescription Pain Relievers

Your physician may suggest physical therapy. Your CIDP symptoms can be manageable, where you might only need over-the-counter pain relievers. For pain that is harder to manage, your doctor might prescribe prescription-strength pain relievers.

All pain relievers come with risks — even over-the-counter drugs. However, narcotic pain relievers carry the most risk. With narcotic pain relievers, you may experience:

  • An intense high 
  • Random muscle spasms
  • Reduced ability to react quickly
  • Nausea or/and vomiting
  • Diarrhea
  • Risk of long-term abuse and addiction

There’s a broad range of second-line drugs doctors may use to treat CIDP. These, however, usually only come into play if the treatments above fail. These medications are often not tested in randomized controlled trials, and some of them have significant side effects. However, their use is based on medical literature and case series.

Cannabis for CIDP

Due to that fact that neuropathic pain is often refractory to conventional prescription remedies, sometimes an alternative treatment option such as marijuana is necessary. One compound in medical marijuana, (E)-BCP (beta-caryophyllene), is an anti-inflammatory, but doesn't affect the molecular receptor that makes you feel stoned.

e-bcp

Instead, this compound could help a condition such as CIDP because it activates only the CB2 receptor, which plays a key role in alleviating inflammation. Inflammation is necessary for wounds and infections to heal. However, chronic inflammation can lead to a host of diseases, such as atherosclerosis, rheumatoid arthritis and even cancer.

If you take medical cannabis as prescribed, it's usually safe. Mild side effects you might experience include:

  • Dry mouth
  • Dry or red eyes
  • Nausea
  • Vomiting

You may recover completely from CIDP. However, many individuals end up living with symptoms of nerve damage like weakness or numbness.

How and Why Marijuana Is an Effective Treatment for CIDP

The pain you experience from CIDP is similar to other types of pain, especially pain associated with multiple sclerosis. Medical cannabis for CIDP treatment has been very successful in patients. Pot can help reduce inflammation and pain. It can also help relieve muscle spasms, tingling sensations and other symptoms related to CIDP.

Recent studies of cannabis and CIDP treatment showed that at low doses, weed is useful, and significantly reduces neuropathic pain and improves sleep. 

Even raw cannabis has benefits for treating CIDP. This is due to the compound (E)-BCP (beta-caryophyllene) that activates the CB2 receptor, which is what makes it so effective.

Although there isn't any treatment that can stop the progression of CIDP at the moment, medical cannabis can potentially slow it down due to its anti-inflammatory properties, which have a stabilizing effect on the pathways that influence how severe your immune response is. 

CIDP involves your body attacking its healthy cells, and medical cannabis can help repress the strength of those effects. Your CIDP will not progress as fast when there's a decline in healthy cells being destroyed.

What Symptoms of CIPD Can Marijuana Treat?

Marijuana for CIPD symptoms is effective in reducing:

  • Pain
  • Diarrhea
  • Nausea
  • Depression
  • Mood swings
  • Insomnia and fatigue

Weed helps improve sleep patterns and helps with chronic fatigue and insomnia. 

Best Strains of Marijuana to Use for CIPD 

Strains with high cannabidiol content are good for calming down muscle spasms, treating extreme nerve pain and reducing joint stiffness and inflammation. Strains that are high in cannabidiol content are also good for treating convulsions, muscle spasms and nerve pain. You will experience a mild sedative effect, so it’s perfect if you're struggling with insomnia.

high cannaboidiol content

High cannabidiol content strains also have antidepressant properties.

  • Indica strains have high THC content, making these strains perfect for people who are in pain, struggle with insomnia or are burdened with anxiety or stress.
  • Sativa strains are also high in THC. They have uplifting and energetic properties, making them perfect for people who are battling depression or don't have much of an appetite anymore, which depression often causes.
  • Hybrid strains mix both sativa and indica weed varieties, so you get all the medicinal and recreational qualities of cannabis. Each strain will vary in effect.

All the strains below are great for treating symptoms of CIDP, including:

  • Pain and inflammation
  • Muscle spasms and weakness
  • Stress and anxiety
  • Insomnia
  • Depression

Your budtender and medical marijuana doctor can help you select the best strain for you. Some potential strains to consider include:

  • ACDC (hybrid): A strain that’s good for treating anxiety, pain, epilepsy and multiple sclerosis, a disease with similar symptoms to CIDP. 
  • Blue Cheese (indica): A strain that has heavy indica effects, which is excellent for those who need pain relief or are struggling with muscle spasms. It’s good for stress, too.
  • OG Kush (hybrid): A strain that crushes stress because of its heavy euphoric effect. It's a good strain for stress disorders and combating stress associated with CIDP.
  • Island Sweet Skunk (sativa): Certain varieties of this strain contain high cannabidiol content, helping patients with inflammation, muscle spasms and anxiety. 
  • Silver Haze (sativa): A strain, although strong, that provides you with the clear-headed sativa effects. It helps uplift your mood and therefore is a good strain to help with depression.
  • Blackwater (indica): A strain that starts off as a euphoric and mellow experience that gradually flows into your body, giving you a head-to-toe, fully euphoric calm. It's great for relieving anxiety and stress. The Blackwater strain may also help treat appetite loss and pain.
  • Afghani (indica): A strain that gives you a euphoric and sedating effect, which is why many patients turn to it to relieve their pain, insomnia and stress.

To shop for a marijuana and CIDP strain and find a prescribing physician, use our search directory to find a medical marijuana dispensary or doctor. MarijuanaDoctors.com can connect you with marijuana doctors in all legal marijuana states and ensure you are in compliance with your state laws. Book your appointment and let us help improve your quality of life!

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This information is not provided by medical professionals and is intended only to complement, and not to replace or contradict, any health or medical advice or information provided by healthcare professionals.  If you have any questions, please contact your doctor or other healthcare professional.

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